Abstact- Purpose : The research aimed to develop a nursing information system in order to simplify the admission procedure for caring clinical in-patient, enhance the effiency of medical information system in order to simplify the admission procedure for caring clinical in-patient, enhance the efficiency of medical information documentation. Therefore, by correctly delivering patients’ health records, and providing continues care, patient safety and care quality would be effectively improved. Methods : the study method was to apply Spiral Model development system to compos a nursing information team. By using strategies of data collection, working environment observation, applying use-case modeling, and conferences of joint Application Design (JAD) to complete the system requirement analysis and design. The Admision Care Management Information System (ACMIS) mainly included: (1) admission nursing management information system . (2) inter-shift meeting information management system. (3) the linkage of drug management system and physical examination record system. The framework contained qualitative and quantitative components that provided both formative and summative elements of the evaluation. System evaluation was to aply information success model, and developed questionnaire of consisting nurses’ acceptance and satisfaction. The results of a total 309 questionnaires were: users’ statisfaction, the perceived self involvement, age and information quality were positively to personal and organizational effectiveness. (65.3% effectiveness =0.771 +.550x users’ satisfaction +.238xNurses’Involvement+.110xage+.114x NIS quality). According to the results of this study, the Admision Care Management Information System was practical to simpliftying clinic working procedure and effective in communicating and documenting admission medical information. Keywords: admission care ; in-patient ; nursing information system