Hospital Information System (HIS) is expected to provide the staffs with various, world-wide information for decision making and better communication environment. The Internet can satisfy such needs. When HIS aims the direction toward an integrated environment with the Internet, several key issues should be discussed. The first important issue is that the Internet environment should be available everywhere in a The second is communication hospital. environment between hospitals. The third is sharing medical knowledge among hospitals and clinics. The forth is how to create a useful high-quality database available through the Internet. And the last is the security issue.