abstract-this research aims to develop a model of disease prevention and control of LAO's network and to assess and set the priority of the needs for development of LAO's network. The study areas were in Sri Sa Ket, Amnat Charoen, Nakon provinces. The research was designed by mixed methods of both qualitative and quantitative data collection. The target group on quantitative data consisted of 206 representatives of LAOs and another 60 representatives from 12 LAOs . The priority needs index (PNI modified) was used for analyzing and setting the priority of needs on disease prevention and control. The atlas ti . program was used for coding the qualitative data and then analyzing the main issues. Research Findings: The first priority needs of disease prevention and control were on setting "the planning and evaluation of the project". On giving knowledge of disease prevention and control to people was under the heading of "needs of knpwledge on occupational disease and environment".On the communication on disease prevention and control was under the heading of "the communication toward the public communication of the community". The model of LAO's network on disease prevention and control in the area of the office of disease prevention and control, Region 7th in Ubon Ratchathani province comprised three networks:skills development on planning and evaluating, knowledge development on disease prevention and control,and communication on disease prevention and control. keyword:network/needs/disease prevention and control/local administration organization