Abstract- Hospital information system (HIS) has been successfully being implemented in Malaysia since 1998. However, there is little research being conducted to evaluate the level of satisfaction among the system’s user. There is a need for more investigation and researches being conducted to investigate the quality of the system. The main objective of this empirical study is to investigate the level of user satisfaction of using HIS in Malaysia. The data was analyzed by using kruskal-wallis. Survey data of 248 two different hospital in Malaysia that uses similar HIS were used. The users include physicians, nurses, laboratory technologies, pharmacists and others. The results show that there are significant differences between different types of users for HIS in Malaysia in terms of the (i) quality of HIS interface, (ii) quality of HIS function, (iii) quality of HIS performance and (iv) quality of HIS (combination of HIS interface, HIS function respondents from and HIS performance). Thus, provide indication for customization and better understanding for different type of HIS users to improve the quality of HIS from end-user’s perspectives. Keywords-system evaluation, hospital information system, human computer interaction